Calix[5]arene Self‐Folding Cavitands: a New Family of Bio‐Inspired Receptors with Enhanced Induced Fit Behavior

Abstract Self‐folding cavitands represent the quintessential form of bioinspired synthetic receptors, featuring deep hydrophobic cavities that engage in host‐guest chemistry reminiscent operating biomolecules. Although remarkable proof‐of‐concept applications have been reported, narrow and rigid spaces legacy resorcin[4]arene derived hosts constitute a liability towards development specific catalysis, sensing or sequestration. While notable efforts to expand size confined reproducing highly adaptable nature biological receptors is largely unaddressed issue. This review summarizes new family calix[5]arene self‐folding displaying enhanced induced fit conformational selection phenomena. Our approach capitalizes on hydrogen bonding preorganization rather than covalent restriction approaches customary conventional supramolecular chemistry.